Please use this identifier to cite or link to this item: https://doi.org/10.1021/ol2021274
Title: Organocatalytic asymmetric aldol reaction of hydroxyacetone with β,γ-unsaturated α-keto esters: Facile access to chiral tertiary alcohols
Authors: Liu, C.
Dou, X.
Lu, Y. 
Issue Date: 7-Oct-2011
Citation: Liu, C., Dou, X., Lu, Y. (2011-10-07). Organocatalytic asymmetric aldol reaction of hydroxyacetone with β,γ-unsaturated α-keto esters: Facile access to chiral tertiary alcohols. Organic Letters 13 (19) : 5248-5251. ScholarBank@NUS Repository. https://doi.org/10.1021/ol2021274
Abstract: An efficient direct asymmetric aldol reaction between hydroxyacetone and β,γ-unsaturated α-keto esters has been successfully developed. In the presence of 9-amino-9-deoxy-epi-cinchonine and trifluoroacetic acid, the direct aldol reaction of O-protected hydroxyacetone proceeded in a highly enantioselective manner, affording the desired adducts containing a chiral tertiary alcohol in high yields and with excellent enantioselectivities. The aldol products obtained are valuable precursors for the synthesis of 2-substituted glycerol derivatives. © 2011 American ChemicalSociety.
Source Title: Organic Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/76701
ISSN: 15237060
DOI: 10.1021/ol2021274
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