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|Title:||Organocatalytic asymmetric aldol reaction of hydroxyacetone with β,γ-unsaturated α-keto esters: Facile access to chiral tertiary alcohols|
|Citation:||Liu, C., Dou, X., Lu, Y. (2011-10-07). Organocatalytic asymmetric aldol reaction of hydroxyacetone with β,γ-unsaturated α-keto esters: Facile access to chiral tertiary alcohols. Organic Letters 13 (19) : 5248-5251. ScholarBank@NUS Repository. https://doi.org/10.1021/ol2021274|
|Abstract:||An efficient direct asymmetric aldol reaction between hydroxyacetone and β,γ-unsaturated α-keto esters has been successfully developed. In the presence of 9-amino-9-deoxy-epi-cinchonine and trifluoroacetic acid, the direct aldol reaction of O-protected hydroxyacetone proceeded in a highly enantioselective manner, affording the desired adducts containing a chiral tertiary alcohol in high yields and with excellent enantioselectivities. The aldol products obtained are valuable precursors for the synthesis of 2-substituted glycerol derivatives. © 2011 American ChemicalSociety.|
|Source Title:||Organic Letters|
|Appears in Collections:||Staff Publications|
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