Please use this identifier to cite or link to this item: https://doi.org/10.1002/smll.201201765
Title: NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release
Authors: Yang, Y.
Velmurugan, B.
Liu, X. 
Xing, B.
Keywords: drug delivery
nanoparticles
photoresponse
upconversion
Issue Date: 9-Sep-2013
Source: Yang, Y., Velmurugan, B., Liu, X., Xing, B. (2013-09-09). NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release. Small 9 (17) : 2937-2944. ScholarBank@NUS Repository. https://doi.org/10.1002/smll.201201765
Abstract: An NIR-responsive mesoporous silica coated upconverting nanoparticle (UCNP) conjugate is developed for controllable drug delivery and fluorescence imaging in living cells. In this work, antitumor drug doxorubicin (Dox) molecules are encapsulated within cross-linked photocaged mesoporous silica coated UCNPs. Upon 980 nm light irradiation, Dox could be selectively released through the photocleavage of theo-nitrobenzyl (NB) caged linker by the converted UV emission from UCNPs. This NIR light-responsive nanoparticle conjugate demonstrates high efficiency for the controlled release of the drug in cancer cells. Upon functionalization of the nanocarrier with folic acid (FA), this photocaged FA-conjugated silica-UCNP nanocarrier will also allow targeted intracellular drug delivery and selective fluorescence imaging towards the cell lines with high level expression of folate receptor (FR). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Small
URI: http://scholarbank.nus.edu.sg/handle/10635/76638
ISSN: 16136810
DOI: 10.1002/smll.201201765
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

97
checked on Feb 27, 2018

WEB OF SCIENCETM
Citations

94
checked on Feb 27, 2018

Page view(s)

38
checked on Apr 20, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.