Please use this identifier to cite or link to this item: https://doi.org/10.1021/jf400144s
Title: New stilbenoids isolated from fungus-challenged black skin peanut seeds and their adipogenesis inhibitory activity in 3T3-L1 cells
Authors: Liu, Z.
Wu, J.
Huang, D. 
Keywords: antiadipogenicity
arachidin
Arachis hypogaea
arahypin
dimers
peanut seeds
stilbene
Issue Date: 1-May-2013
Source: Liu, Z., Wu, J., Huang, D. (2013-05-01). New stilbenoids isolated from fungus-challenged black skin peanut seeds and their adipogenesis inhibitory activity in 3T3-L1 cells. Journal of Agricultural and Food Chemistry 61 (17) : 4155-4161. ScholarBank@NUS Repository. https://doi.org/10.1021/jf400144s
Abstract: One new stilbene derivative (3,5,3′-trihydroxy-4′-methoxy- 5′-isopentenylstilbene, MIP) and two new stilbene dimers (arahypin-11 and arahypin-12) together with three known stilbenoids (arachidin-1, arachidin-3, and SB-1) were isolated from black skin peanut seeds challenged by the fungal strain Rhizopus oligoporus. The structures of the three new compounds were elucidated by analysis of HRESIMS, UV, 1D and 2D NMR spectra. The antiadipogenic and cytotoxic effects of the isolated compounds were investigated using 3T3-L1 cells at a concentration range of 1-10 μM. Among the compounds tested, arachidin-1 inhibited the 3T3-L1 adipocyte differentiation dose-dependently, whereas arahypin-11 and arahypin-12 exhibited significant cytotoxicity in 3T3-L1 preadipocytes. © 2013 American Chemical Society.
Source Title: Journal of Agricultural and Food Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/76634
ISSN: 00218561
DOI: 10.1021/jf400144s
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