Please use this identifier to cite or link to this item: https://doi.org/10.1055/s-2002-23142
Title: Mitochondrial destabilisation and caspase-3 activation are involved in the apoptosis of Jurkat cells induced by gaudichaudione A, a cytotoxic xanthone
Authors: Wu, X.
Cao, S.
Goh, S. 
Hsu, A.
Tan, B.K.H.
Keywords: Annexin V
Apoptosis
Caspases
Flow cytometry
Gaudichaudione A
Mitochondrial transmembrane potential
Issue Date: 2002
Citation: Wu, X., Cao, S., Goh, S., Hsu, A., Tan, B.K.H. (2002). Mitochondrial destabilisation and caspase-3 activation are involved in the apoptosis of Jurkat cells induced by gaudichaudione A, a cytotoxic xanthone. Planta Medica 68 (3) : 198-203. ScholarBank@NUS Repository. https://doi.org/10.1055/s-2002-23142
Abstract: Gaudichaudione A, a cytotoxic xanthone obtained from Garcinia gaudichaudii, displayed strong growth inhibitory effects against Jurkat human leukemic cells, parental murine leukemic P388 and P388/DOX-resistant cell lines, and exhibited similar cytotoxicity against P388/DOX as well as P388, but was less toxic toward normal human Chang liver cells. A variety of apoptotic events induced by gaudichaudione A at the mitochondrial and nuclear levels has been characterized. It appears that gaudichaudione A induced a collapse of the mitochondrial transmembrane potential. Caspase-3 was activated and induced internucleosomal DNA fragmentation and externalization of PS residues. The apoptotic features were also observed in ultrastructural studies.
Source Title: Planta Medica
URI: http://scholarbank.nus.edu.sg/handle/10635/76576
ISSN: 00320943
DOI: 10.1055/s-2002-23142
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