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https://doi.org/10.1055/s-2002-23142
Title: | Mitochondrial destabilisation and caspase-3 activation are involved in the apoptosis of Jurkat cells induced by gaudichaudione A, a cytotoxic xanthone | Authors: | Wu, X. Cao, S. Goh, S. Hsu, A. Tan, B.K.H. |
Keywords: | Annexin V Apoptosis Caspases Flow cytometry Gaudichaudione A Mitochondrial transmembrane potential |
Issue Date: | 2002 | Citation: | Wu, X., Cao, S., Goh, S., Hsu, A., Tan, B.K.H. (2002). Mitochondrial destabilisation and caspase-3 activation are involved in the apoptosis of Jurkat cells induced by gaudichaudione A, a cytotoxic xanthone. Planta Medica 68 (3) : 198-203. ScholarBank@NUS Repository. https://doi.org/10.1055/s-2002-23142 | Abstract: | Gaudichaudione A, a cytotoxic xanthone obtained from Garcinia gaudichaudii, displayed strong growth inhibitory effects against Jurkat human leukemic cells, parental murine leukemic P388 and P388/DOX-resistant cell lines, and exhibited similar cytotoxicity against P388/DOX as well as P388, but was less toxic toward normal human Chang liver cells. A variety of apoptotic events induced by gaudichaudione A at the mitochondrial and nuclear levels has been characterized. It appears that gaudichaudione A induced a collapse of the mitochondrial transmembrane potential. Caspase-3 was activated and induced internucleosomal DNA fragmentation and externalization of PS residues. The apoptotic features were also observed in ultrastructural studies. | Source Title: | Planta Medica | URI: | http://scholarbank.nus.edu.sg/handle/10635/76576 | ISSN: | 00320943 | DOI: | 10.1055/s-2002-23142 |
Appears in Collections: | Staff Publications |
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