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|Title:||Laetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia|
|Authors:||Lear, M.J. |
La Clair, J.J.
|Citation:||Lear, M.J., Simon, O., Foley, T.L., Burkart, M.D., Baiga, T.J., Noel, J.P., DiPasquale, A.G., Rheingold, A.L., La Clair, J.J. (2009-11-30). Laetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia. Journal of Natural Products 72 (11) : 1980-1987. ScholarBank@NUS Repository. https://doi.org/10.1021/np9002838|
|Abstract:||(±)-Laetirobin (1) was isolated as a cytostatic lead from Laetiporus sulphureus growing parasitically on the black locust tree, Robinia pseudoacacia, by virtue of a reverse-immunoaffinity system. Using an LC/MS procedure, milligram quantities of (±)-laetirobin (1) were obtained, and the structure of 1 was elucidated by X-ray crystallography and confirmed by NMR spectroscopy. Preliminary cellular studies indicated that (±)-laetirobin (1) rapidly enters in tumor cells, blocks cell division at a late stage of mitosis, and invokes apoptosis. © 2009 American Chemical Society and American Society of Pharmacognosy.|
|Source Title:||Journal of Natural Products|
|Appears in Collections:||Staff Publications|
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