Please use this identifier to cite or link to this item: https://doi.org/10.1039/c0ja00195c
Title: Isotopic signatures of iron in body tissues as a potential biomarker for iron metabolism
Authors: Hotz, K.
Augsburger, H.
Walczyk, T. 
Issue Date: May-2011
Source: Hotz, K., Augsburger, H., Walczyk, T. (2011-05). Isotopic signatures of iron in body tissues as a potential biomarker for iron metabolism. Journal of Analytical Atomic Spectrometry 26 (7) : 1347-1353. ScholarBank@NUS Repository. https://doi.org/10.1039/c0ja00195c
Abstract: Previous studies using MC-ICP-MS for high precision isotope ratio analysis revealed that human blood is enriched in light iron isotopes relative to dietary iron. Moreover, distinct differences in blood iron isotopic patterns between individual subjects can be observed. Discrimination of heavy iron isotopes during uptake of dietary iron in the gastrointestinal tract may explain this observation. This hypothesis was now tested in the pig model. Samples of tissues relevant to iron metabolism were screened for iron isotopic patterns using MC-ICP-MS, revealing considerable isotope fractionation during intestinal uptake on one hand and during distribution between body tissues on the other hand. Light iron isotopes are enriched in the gastrointestinal mucosa relative to feed, with isotopic patterns reflecting major iron absorption sites in mammals along the gut. While heavy iron isotopes are enriched in the liver, spleen and bone marrow, light isotopes are enriched in red blood cells. Well-established links between iron absorption efficiency and iron distribution between functional compartments and stores point to blood iron isotope signatures as a novel type of compound biomarker of element metabolism. © 2011 The Royal Society of Chemistry.
Source Title: Journal of Analytical Atomic Spectrometry
URI: http://scholarbank.nus.edu.sg/handle/10635/76419
ISSN: 02679477
DOI: 10.1039/c0ja00195c
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