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https://doi.org/10.1002/chem.201002490
| Title: | Enantioselective synthesis of densely functionalized pyranochromenes via an unpredictable cascade Michael-oxa-Michael-tautomerization sequence | Authors: | Ren, Q. Gao, Y. Wang, J. |
Keywords: | asymmetric catalysis cascade reaction chromene organocatalysis thiourea |
Issue Date: | 10-Dec-2010 | Citation: | Ren, Q., Gao, Y., Wang, J. (2010-12-10). Enantioselective synthesis of densely functionalized pyranochromenes via an unpredictable cascade Michael-oxa-Michael-tautomerization sequence. Chemistry - A European Journal 16 (46) : 13594-13598. ScholarBank@NUS Repository. https://doi.org/10.1002/chem.201002490 | Abstract: | A surprising example of enantioselective cascade Michael-oxa-Michael- tautomerization reactions of malononitrile and benzylidenechromanones has been developed. In this case, malononitrile functions as both nucleophile and electrophile. Meanwhile, a simple bifunctional indane amine-thiourea catalyst has been discovered to promote this process to afford high yields (up to 99%) and high to excellent enantiomeric excesses (81-99% ee). Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | Source Title: | Chemistry - A European Journal | URI: | http://scholarbank.nus.edu.sg/handle/10635/76111 | ISSN: | 09476539 | DOI: | 10.1002/chem.201002490 |
| Appears in Collections: | Staff Publications |
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