Please use this identifier to cite or link to this item: https://doi.org/10.1002/chem.201002490
Title: Enantioselective synthesis of densely functionalized pyranochromenes via an unpredictable cascade Michael-oxa-Michael-tautomerization sequence
Authors: Ren, Q.
Gao, Y.
Wang, J. 
Keywords: asymmetric catalysis
cascade reaction
chromene
organocatalysis
thiourea
Issue Date: 10-Dec-2010
Citation: Ren, Q., Gao, Y., Wang, J. (2010-12-10). Enantioselective synthesis of densely functionalized pyranochromenes via an unpredictable cascade Michael-oxa-Michael-tautomerization sequence. Chemistry - A European Journal 16 (46) : 13594-13598. ScholarBank@NUS Repository. https://doi.org/10.1002/chem.201002490
Abstract: A surprising example of enantioselective cascade Michael-oxa-Michael- tautomerization reactions of malononitrile and benzylidenechromanones has been developed. In this case, malononitrile functions as both nucleophile and electrophile. Meanwhile, a simple bifunctional indane amine-thiourea catalyst has been discovered to promote this process to afford high yields (up to 99%) and high to excellent enantiomeric excesses (81-99% ee). Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Chemistry - A European Journal
URI: http://scholarbank.nus.edu.sg/handle/10635/76111
ISSN: 09476539
DOI: 10.1002/chem.201002490
Appears in Collections:Staff Publications

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