Please use this identifier to cite or link to this item: https://doi.org/10.1021/ol102597s
Title: Enantioselective Morita-Baylis-Hillman reaction of isatins with acrylates: Facile creation of 3-hydroxy-2-oxindoles
Authors: Zhong, F.
Chen, G.-Y.
Lu, Y. 
Issue Date: 7-Jan-2011
Citation: Zhong, F., Chen, G.-Y., Lu, Y. (2011-01-07). Enantioselective Morita-Baylis-Hillman reaction of isatins with acrylates: Facile creation of 3-hydroxy-2-oxindoles. Organic Letters 13 (1) : 82-85. ScholarBank@NUS Repository. https://doi.org/10.1021/ol102597s
Abstract: The first tertiary amine catalyzed enantioselective Morita-Baylis-Hillman (MBH) reaction of isatins with acrylates has been demonstrated, allowing asymmetric synthesis of biologically significant 3-substituted-3-hydroxy-2- oxindoles in good yields and with excellent enantioselectivities. The C6′-OH group of β-isocupreidine (β-ICD) is believed to facilitate the key proton transfer step in the MBH reaction, via an intramolecular proton relay process. © 2010 American Chemical Society.
Source Title: Organic Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/76103
ISSN: 15237060
DOI: 10.1021/ol102597s
Appears in Collections:Staff Publications

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