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|Title:||Enantioselective Morita-Baylis-Hillman reaction of isatins with acrylates: Facile creation of 3-hydroxy-2-oxindoles|
|Citation:||Zhong, F., Chen, G.-Y., Lu, Y. (2011-01-07). Enantioselective Morita-Baylis-Hillman reaction of isatins with acrylates: Facile creation of 3-hydroxy-2-oxindoles. Organic Letters 13 (1) : 82-85. ScholarBank@NUS Repository. https://doi.org/10.1021/ol102597s|
|Abstract:||The first tertiary amine catalyzed enantioselective Morita-Baylis-Hillman (MBH) reaction of isatins with acrylates has been demonstrated, allowing asymmetric synthesis of biologically significant 3-substituted-3-hydroxy-2- oxindoles in good yields and with excellent enantioselectivities. The C6′-OH group of β-isocupreidine (β-ICD) is believed to facilitate the key proton transfer step in the MBH reaction, via an intramolecular proton relay process. © 2010 American Chemical Society.|
|Source Title:||Organic Letters|
|Appears in Collections:||Staff Publications|
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