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Title: Diversity-oriented fluorescence library approach (DOFLA) to the discovery of chymotrypsin sensor
Authors: Wang, S.
Yun, K.K.
Chang, Y.-T. 
Issue Date: May-2008
Citation: Wang, S., Yun, K.K., Chang, Y.-T. (2008-05). Diversity-oriented fluorescence library approach (DOFLA) to the discovery of chymotrypsin sensor. Journal of Combinatorial Chemistry 10 (3) : 460-465. ScholarBank@NUS Repository.
Abstract: The diversity-oriented fluorescence library approach (DOFLA) has emerged and found applications in various fields to meet the acute demands for novel fluorescence sensors. The power of this approach has been demonstrated with the impressive discoveries of novel sensors for polymers such as DNA and heparin or for small molecules such as GTP and glutathione (J. Am. Chem. Soc. 2003, 125, 1130-1131; J. Am. Chem. Soc. 2006, 128, 10380-10381; J. Am. Chem. Soc. 2007, 129, 4510-4511; Chem. Commun. [Online early access]. DOI: 10.1039/b717058k. Published online Dec 11, 2008. article.asp?doi=b717058k). Herein we report the application of this approach on quinaldinium fluorescent dye library synthesis on solid support and novel chymotrypsin sensor discovery. The new sensors are not only selective to chymotrypsin over other proteins but also only to the active conformation of chymotrypsin. © 2008 American Chemical Society.
Source Title: Journal of Combinatorial Chemistry
ISSN: 15204766
DOI: 10.1021/cc700189b
Appears in Collections:Staff Publications

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