Please use this identifier to cite or link to this item: https://doi.org/10.1007/BF00123408
Title: Dimethyl sulfoxide as an anticalcification agent for glutaraldehyde-fixed biological tissue
Authors: Khor, E. 
Wee, A.
Loke, W.K.
Tan, B.L.
Issue Date: Nov-1996
Source: Khor, E., Wee, A., Loke, W.K., Tan, B.L. (1996-11). Dimethyl sulfoxide as an anticalcification agent for glutaraldehyde-fixed biological tissue. Journal of Materials Science: Materials in Medicine 7 (11) : 691-693. ScholarBank@NUS Repository. https://doi.org/10.1007/BF00123408
Abstract: Dimethylsulfoxide has been found to mitigate the calcification of glutaraldehyde-fixed biological tissue in the rat subdermal model. This effect is achieved with neat dimethylsulfoxide either prior to or after glutaraldehyde fixation of the biological tissue. The calcium levels for the 21 days post-implant for both methods are over 20 times less than the controls. However, fixation of the tissue with glutaraldehyde before dimethylsulfoxide treatment appears to better control calcification over the longer term. Histological examination of samples after exposure before or after implantation show no deleterious effects to the tissue due to dimethylsulfoxide.
Source Title: Journal of Materials Science: Materials in Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/75943
ISSN: 09574530
DOI: 10.1007/BF00123408
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