Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0021-9673(97)01269-7
Title: Degradation study of unsaturated anhydrides by reversed-phase high- performance liquid chromatography
Authors: Liu, W.
Lee, H.K. 
Keywords: Anhydrides
Kinetic studies
Stability studies
Issue Date: 1-May-1998
Source: Liu, W., Lee, H.K. (1998-05-01). Degradation study of unsaturated anhydrides by reversed-phase high- performance liquid chromatography. Journal of Chromatography A 805 (1-2) : 109-118. ScholarBank@NUS Repository. https://doi.org/10.1016/S0021-9673(97)01269-7
Abstract: In this report, the applicability of reversed-phase high-performance liquid chromatography (HPLC) to the degradation and kinetic studies of unsaturated anhydrides is explored. Under the appropriate HPLC conditions, the separation and determination of anhydrides were achieved. After comparing their stabilities in methanol, acetonitrile and pure water, the hydrolytic behavior of anhydrides was further evaluated using varying proportions of aqueous phase and acidity for hydrolysis. On the basis of a nucleophilic- attack pathway, the stability and hydrolytic velocity of the anhydrides were compared. The results showed that the hydrolytic processes of the anhydrides could be described with first-order equations, and the corresponding hydrolytic rate constants were calculated from the experimental data.
Source Title: Journal of Chromatography A
URI: http://scholarbank.nus.edu.sg/handle/10635/75859
ISSN: 00219673
DOI: 10.1016/S0021-9673(97)01269-7
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