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|Title:||Combinatorial solid-phase synthesis of 4,6-diaryl and 4-aryl, 6-alkyl-1,3,5-triazines and their application to efficient biofuel production|
|Citation:||Kim, J.Y.H., Lee, J.W., Lee, W.S., Ha, H.-H., Vendrell, M., Bork, J.T., Lee, Y., Chang, Y.-T. (2012-07-09). Combinatorial solid-phase synthesis of 4,6-diaryl and 4-aryl, 6-alkyl-1,3,5-triazines and their application to efficient biofuel production. ACS Combinatorial Science 14 (7) : 395-398. ScholarBank@NUS Repository. https://doi.org/10.1021/co300007a|
|Abstract:||Herein we report the solid-phase synthesis of a combinatorial aryl, alkyl-triazine library and its application to biofuel production. The combination of Grignard reactions and solid supported Suzuki coupling reactions afforded unique 120 triazine compounds with high purities and minimum purification steps. Through an unbiased phenotypic screening for improved biofuel generation in oleaginous yeast, we found one diaryl triazine derivative (E4) which increased the biolipid production up to 86%. © 2012 American Chemical Society.|
|Source Title:||ACS Combinatorial Science|
|Appears in Collections:||Staff Publications|
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