Combinatorial solid-phase synthesis of 4,6-diaryl and 4-aryl, 6-alkyl-1,3,5-triazines and their application to efficient biofuel production

Please use this identifier to cite or link to this item: https://doi.org/10.1021/co300007a

Title:	Combinatorial solid-phase synthesis of 4,6-diaryl and 4-aryl, 6-alkyl-1,3,5-triazines and their application to efficient biofuel production
Authors:	Kim, J.Y.H. Lee, J.W. Lee, W.S. Ha, H.-H. Vendrell, M. Bork, J.T. Lee, Y. Chang, Y.-T.
Keywords:	biolipids chemical genetics Grignard reaction high-throughput screening Suzuki coupling triazines
Issue Date:	9-Jul-2012
Citation:	Kim, J.Y.H., Lee, J.W., Lee, W.S., Ha, H.-H., Vendrell, M., Bork, J.T., Lee, Y., Chang, Y.-T. (2012-07-09). Combinatorial solid-phase synthesis of 4,6-diaryl and 4-aryl, 6-alkyl-1,3,5-triazines and their application to efficient biofuel production. ACS Combinatorial Science 14 (7) : 395-398. ScholarBank@NUS Repository. https://doi.org/10.1021/co300007a
Abstract:	Herein we report the solid-phase synthesis of a combinatorial aryl, alkyl-triazine library and its application to biofuel production. The combination of Grignard reactions and solid supported Suzuki coupling reactions afforded unique 120 triazine compounds with high purities and minimum purification steps. Through an unbiased phenotypic screening for improved biofuel generation in oleaginous yeast, we found one diaryl triazine derivative (E4) which increased the biolipid production up to 86%. © 2012 American Chemical Society.
Source Title:	ACS Combinatorial Science
URI:	http://scholarbank.nus.edu.sg/handle/10635/75775
ISSN:	21568952
DOI:	10.1021/co300007a
Appears in Collections:	Staff Publications

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