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|Title:||Chiral bicyclic guanidines: A concise and efficient aziridine-based synthesis|
|Source:||Ye, W., Leow, D., Goh, S.L.M., Tan, C.-T., Chian, C.-H., Tan, C.-H. (2006-02-06). Chiral bicyclic guanidines: A concise and efficient aziridine-based synthesis. Tetrahedron Letters 47 (6) : 1007-1010. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tetlet.2005.11.133|
|Abstract:||A series of chiral bicyclic guanidines, either symmetrical or non-symmetrical, was synthesized using a concise and efficient aziridine-based synthetic methodology. Starting from commercial amino alcohols, five synthetic steps were performed, with only three requiring chromatographic purification, giving the desired guanidines in 43-71% overall yield. Preliminary studies using these guanidines showed moderate enantioselectivity for several Michael reactions. © 2005 Elsevier Ltd. All rights reserved.|
|Source Title:||Tetrahedron Letters|
|Appears in Collections:||Staff Publications|
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