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https://doi.org/10.1016/j.tetlet.2005.11.133
| Title: | Chiral bicyclic guanidines: A concise and efficient aziridine-based synthesis | Authors: | Ye, W. Leow, D. Goh, S.L.M. Tan, C.-T. Chian, C.-H. Tan, C.-H. |
Keywords: | Aziridine Enantioselectivity Guanidine Michael reaction Regioselectivity |
Issue Date: | 6-Feb-2006 | Citation: | Ye, W., Leow, D., Goh, S.L.M., Tan, C.-T., Chian, C.-H., Tan, C.-H. (2006-02-06). Chiral bicyclic guanidines: A concise and efficient aziridine-based synthesis. Tetrahedron Letters 47 (6) : 1007-1010. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tetlet.2005.11.133 | Abstract: | A series of chiral bicyclic guanidines, either symmetrical or non-symmetrical, was synthesized using a concise and efficient aziridine-based synthetic methodology. Starting from commercial amino alcohols, five synthetic steps were performed, with only three requiring chromatographic purification, giving the desired guanidines in 43-71% overall yield. Preliminary studies using these guanidines showed moderate enantioselectivity for several Michael reactions. © 2005 Elsevier Ltd. All rights reserved. | Source Title: | Tetrahedron Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/75746 | ISSN: | 00404039 | DOI: | 10.1016/j.tetlet.2005.11.133 |
| Appears in Collections: | Staff Publications |
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