Bifunctional thiourea-promoted cascade aza-Michael-Henry-dehydration reactions: Asymmetric preparation of 3-nitro-1,2-dihydroquinolines

Please use this identifier to cite or link to this item: https://doi.org/10.1039/c0ob00223b

Title:	Bifunctional thiourea-promoted cascade aza-Michael-Henry-dehydration reactions: Asymmetric preparation of 3-nitro-1,2-dihydroquinolines
Authors:	Liu, X. Lu, Y.
Issue Date:	21-Sep-2010
Citation:	Liu, X., Lu, Y. (2010-09-21). Bifunctional thiourea-promoted cascade aza-Michael-Henry-dehydration reactions: Asymmetric preparation of 3-nitro-1,2-dihydroquinolines. Organic and Biomolecular Chemistry 8 (18) : 4063-4065. ScholarBank@NUS Repository. https://doi.org/10.1039/c0ob00223b
Abstract:	A cascade aza-Michael-Henry-dehydration reaction catalyzed by quinidine-derived tertiary amine-thiourea catalyst was developed via installation of suitable electron withdrawing groups at the amino function of aniline. This strategy led to a one-step preparation of chiral 3-nitro-1,2-dihydroquinolines in high yields and with up to 90% enantiomeric excesses. © 2010 The Royal Society of Chemistry.
Source Title:	Organic and Biomolecular Chemistry
URI:	http://scholarbank.nus.edu.sg/handle/10635/75656
ISSN:	14770520
DOI:	10.1039/c0ob00223b
Appears in Collections:	Staff Publications

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