Asymmetric synthesis of 2-Aryl-2,3-dihydro-4-quinolones via bifunctional thiourea-mediated intramolecular cyclization

Please use this identifier to cite or link to this item: https://doi.org/10.1021/ol102519z

Title:	Asymmetric synthesis of 2-Aryl-2,3-dihydro-4-quinolones via bifunctional thiourea-mediated intramolecular cyclization
Authors:	Liu, X. Lu, Y.
Issue Date:	3-Dec-2010
Citation:	Liu, X., Lu, Y. (2010-12-03). Asymmetric synthesis of 2-Aryl-2,3-dihydro-4-quinolones via bifunctional thiourea-mediated intramolecular cyclization. Organic Letters 12 (23) : 5592-5595. ScholarBank@NUS Repository. https://doi.org/10.1021/ol102519z
Abstract:	A novel asymmetric preparation of optically enriched 2-aryl-2,3- dihydroquinolin-4(1H)-ones has been developed. By installing a sulfonyl group on the nitrogen of the anilines and an ester function on the unsaturated ketones, an intramolecular organocatalytic cyclization took place readily in a stereoselective manner, resulting in the formation of dihydroquinolones with high enantioselectivity. © 2010 American Chemical Society.
Source Title:	Organic Letters
URI:	http://scholarbank.nus.edu.sg/handle/10635/75627
ISSN:	15237060
DOI:	10.1021/ol102519z
Appears in Collections:	Staff Publications

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