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https://doi.org/10.1002/anie.200903635
| Title: | Asymmetric mannich reaction of fluorinated ketoesters with a tryptophan-derived bifunctional thiourea catalyst | Authors: | Han, X. Kwiatkowski, J. Xue, T. Huang, K.-W. Lu, Y. |
Keywords: | Asymmetric synthesis Fluorination Mannich reaction Organocatalysis Quaternary stereocenters |
Issue Date: | 28-Sep-2009 | Citation: | Han, X., Kwiatkowski, J., Xue, T., Huang, K.-W., Lu, Y. (2009-09-28). Asymmetric mannich reaction of fluorinated ketoesters with a tryptophan-derived bifunctional thiourea catalyst. Angewandte Chemie - International Edition 48 (41) : 7604-7607. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.200903635 | Abstract: | Fluorinated quaternary stereocenters: A novel bifunctional catalyst 1 derived from natural tryptophan promoted the Mannich reaction of α-fluoro-β-ketoesters to afford fluorinated chiral molecules containing vicinal quaternary and tertiary stereogenic centers with exceptional enantioselectivity. An unprecedented α-fluoro-β -lactam was also prepared by this method (see scheme; Boc=tert-butoxycarbonyl). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA. | Source Title: | Angewandte Chemie - International Edition | URI: | http://scholarbank.nus.edu.sg/handle/10635/75620 | ISSN: | 14337851 | DOI: | 10.1002/anie.200903635 |
| Appears in Collections: | Staff Publications |
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