Please use this identifier to cite or link to this item: https://doi.org/10.1002/chem.201102097
Title: A versatile thiouronium-based solid-phase synthesis of 1,3,5-triazines
Authors: Kong, K.H.
Tan, C.K.
Lin, X.
Lam, Y. 
Keywords: Microwave chemistry
Nitrogen heterocycles
Solid-phase synthesis
Thiouronium
Triazines
Issue Date: 27-Jan-2012
Citation: Kong, K.H., Tan, C.K., Lin, X., Lam, Y. (2012-01-27). A versatile thiouronium-based solid-phase synthesis of 1,3,5-triazines. Chemistry - A European Journal 18 (5) : 1476-1486. ScholarBank@NUS Repository. https://doi.org/10.1002/chem.201102097
Abstract: A thiouronium-based solidphase synthesis of a 1,3,5-triazine scaffold has been developed. The key feature of the synthesis is the use of a readily accessible solid-supported thiouronium salt as a primary precursor for the stepwise assembly of the 1,3,5-tri-azine substrate. The sulfur linker employed in the synthesis is stable under both acidic and basic conditions and is versatile enough to provide access to monocyclic, bicyclic, and spirocyclic compounds with the 1,3,5-triazine scaffold. By using this synthetic strategy, a representative set of 79 compounds containing the 1,3,5-triazine scaffold were prepared. © 2012 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim.
Source Title: Chemistry - A European Journal
URI: http://scholarbank.nus.edu.sg/handle/10635/75504
ISSN: 09476539
DOI: 10.1002/chem.201102097
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