A highly efficient solid-phase synthesis of 1,3-substituted xanthines

Please use this identifier to cite or link to this item: https://doi.org/10.1021/cc050088i

Title:	A highly efficient solid-phase synthesis of 1,3-substituted xanthines
Authors:	He, R. Lam, Y.
Issue Date:	Nov-2005
Citation:	He, R., Lam, Y. (2005-11). A highly efficient solid-phase synthesis of 1,3-substituted xanthines. Journal of Combinatorial Chemistry 7 (6) : 916-920. ScholarBank@NUS Repository. https://doi.org/10.1021/cc050088i
Abstract:	A first solid-phase route to 1,3-substituted xanthines has been developed using PS-MB-CHO resin. Cyclocondensation of the polymer-bound aminoimidazole with isocyanates followed by alkylation provided 1,3-substituted xanthines in high yields. Libraries of 12 xanthines and 4 thioxanthines were prepared. © 2005 American Chemical Society.
Source Title:	Journal of Combinatorial Chemistry
URI:	http://scholarbank.nus.edu.sg/handle/10635/75426
ISSN:	15204766
DOI:	10.1021/cc050088i
Appears in Collections:	Staff Publications

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