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|Title:||A highly efficient solid-phase synthesis of 1,3-substituted xanthines|
|Citation:||He, R., Lam, Y. (2005-11). A highly efficient solid-phase synthesis of 1,3-substituted xanthines. Journal of Combinatorial Chemistry 7 (6) : 916-920. ScholarBank@NUS Repository. https://doi.org/10.1021/cc050088i|
|Abstract:||A first solid-phase route to 1,3-substituted xanthines has been developed using PS-MB-CHO resin. Cyclocondensation of the polymer-bound aminoimidazole with isocyanates followed by alkylation provided 1,3-substituted xanthines in high yields. Libraries of 12 xanthines and 4 thioxanthines were prepared. © 2005 American Chemical Society.|
|Source Title:||Journal of Combinatorial Chemistry|
|Appears in Collections:||Staff Publications|
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