Endoscope-based autofluorescence imaging and point spectroscopy for improving cancer detection in the larynx

Abstract

Autofluorescence imaging has shown high sensitivity for early diagnosis and detection of cancer in humans. However, it has a limitation diagnostic specificity due to high false positive rates. In our study, we develop an integrated fluorescence endoscopic imaging and point spectroscopy system for real-time tissue measurements. The results show that endoscope-based autofluorescene spectroscopy and imaging system has the potential for improving laryngeal cancer diagnosis and detection. © 2009 Optical Society of America.