Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/74834
Title: Capture of circulating tumor cells (CTCs) using a novel micro-device
Authors: Ranjan, S.
Zhang, Y. 
Keywords: Circulating tumor cells
Microfluidics
Microstructures
Porous membrane
Issue Date: 2012
Source: Ranjan, S.,Zhang, Y. (2012). Capture of circulating tumor cells (CTCs) using a novel micro-device. Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012 : 396-399. ScholarBank@NUS Repository.
Abstract: Circulating tumor cells (CTCs) are metastatic cells that are detached from a tumor and are found in the blood of cancer patients. The presence of CTCs in the blood indicates the metastatic stage of cancer, so the detection of CTCs has been considered as a diagnosis and prognosis marker. Although some efforts have been made to isolate CTCs from blood, it is still challenging due to the rarity of CTCs in blood (approximately one in one billion of blood cells). Apart from some fundamental problems, like non-retrieval of cells from antibody-coated surface, long processing time etc., the main problem with these methods is the loss of cell-viability which impede further study. Here, we demonstrate a novel and efficient micro-device for capturing CTCs at high throughput besides retaining their vaibility. We have fabricated a unique membrane filter with an array of pores where each pore is surrounded by four dome-shaped microstructures. These microstructures extend extra support to cells to maintain their vaibility.
Source Title: Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012
URI: http://scholarbank.nus.edu.sg/handle/10635/74834
ISBN: 9781466562752
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

31
checked on Dec 9, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.