Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/74506
Title: Characterization of frequently sampled intravenous glucose tolerance test using scaling and sensitivity analysis of MINMOD
Authors: Kiran, K.L.
Kandpal, M.
Lakshminarayanan, S. 
Issue Date: 2010
Source: Kiran, K.L.,Kandpal, M.,Lakshminarayanan, S. (2010). Characterization of frequently sampled intravenous glucose tolerance test using scaling and sensitivity analysis of MINMOD. 2010 International Conference on Modelling, Identification and Control, ICMIC 2010 : 179-184. ScholarBank@NUS Repository.
Abstract: Model reduction is an important step in modeling before the model can be deployed for practical applications. Its application to complex biological systems is often very useful. In this work, a minimal model expounding the glucose insulin interactions is considered and scaling analysis is applied to reduce the number of parameters and scale them to ∼O(1). FSIVGTT is one of the diagnostic procedures to check the diabetic condition of an individual. Here, in silico studies are done to characterize the sampling times of existing FSIVGTT. In this regard, global sensitivity analysis is performed on the reduced parametric model to unravel the key parameters influencing the glucose and insulin concentration at the sampling times of FSIVGTT. Overall, this analysis can be beneficial to medical community in designing experiments for implementing novel and efficient diagnostic protocols.
Source Title: 2010 International Conference on Modelling, Identification and Control, ICMIC 2010
URI: http://scholarbank.nus.edu.sg/handle/10635/74506
ISBN: 9780955529337
Appears in Collections:Staff Publications

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