Please use this identifier to cite or link to this item: https://doi.org/10.1117/12.469086
Title: Pulmonary drug delivery using droplets generated by Rayleigh instability-driven breakup of filaments
Authors: Kong, Y.
Xu, Y.
Tay, F.E.H. 
Keywords: Atomisation
MEMS
Microfluidics
Pulmonary drug delivery
Rayleigh instability
Issue Date: 2002
Source: Kong, Y., Xu, Y., Tay, F.E.H. (2002). Pulmonary drug delivery using droplets generated by Rayleigh instability-driven breakup of filaments. Proceedings of SPIE - The International Society for Optical Engineering 4937 : 164-173. ScholarBank@NUS Repository. https://doi.org/10.1117/12.469086
Abstract: For effective pulmonary drug delivery of insulin for example, drug particles must be in the range of 1 to 5 microns. A piezoelectrically actuated MEMS atomizer based on Rayleigh instability-driven breakup of filaments has been designed to produce drug particles in this range. Although the formation of droplets from jets have been used extensively in ink-jet printing, the currently presented mode of droplet formation has not yet been demonstrated by any MEMS device. Testing of the vaporizer reveals that the droplets generated lie primarily in the range of 1.0 - 3.0 microns, a range that covers the designed droplet size of 2.5 microns. We thus show that it is possible to implement this mode of droplet generation that will achieve better device efficiency.
Source Title: Proceedings of SPIE - The International Society for Optical Engineering
URI: http://scholarbank.nus.edu.sg/handle/10635/73791
ISSN: 0277786X
DOI: 10.1117/12.469086
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