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|Title:||Mechanics of the human red blood cell deformed by optical tweezers|
Human red blood cell membrane
|Citation:||Dao, M., Lim, C.T., Suresh, S. (2003-11). Mechanics of the human red blood cell deformed by optical tweezers. Journal of the Mechanics and Physics of Solids 51 (11-12) : 2259-2280. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jmps.2003.09.019|
|Abstract:||The mechanical deformation characteristics of living cells are known to influence strongly their chemical and biological functions and the onset, progression and consequences of a number of human diseases. The mechanics of the human red blood cell (erythrocyte) subjected to large deformation by optical tweezers forms the subject of this paper. Video photography of the cell deformed in a phosphate buffered saline solution at room temperature during the imposition of controlled stretching forces, in the tens to several hundreds picoNewton range, is used to assess experimentally the deformation characteristics. The mechanical responses of the cell during loading and upon release of the optical force are then analysed to extract the elastic properties of the cell membrane by recourse to several different constitutive formulations of the elastic and viscoelastic behavior within the framework of a fully three-dimensional finite element analysis. A parametric study of various geometric, loading and structural factors is also undertaken in order to develop quantitative models for the mechanics of deformation by means of optical tweezers. The outcome of the experimental and computational analyses is then compared with the information available on the mechanical response of the red blood cell from other independent experimental techniques. Potential applications of the optical tweezers method described in this paper to the study of mechanical deformation of living cells under different stress states and in response to the progression of some diseases are also highlighted. © 2003 Elsevier Ltd. All rights reserved.|
|Source Title:||Journal of the Mechanics and Physics of Solids|
|Appears in Collections:||Staff Publications|
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