Please use this identifier to cite or link to this item: https://doi.org/10.2217/nnm.12.88
Title: Tailoring polymeric micelles to optimize delivery to solid tumors
Authors: Li, W.
Feng, S. 
Guo, Y.
Keywords: antibody decorating
block copolymer
drug delivery system
enhanced permeability and retention
intelligent micelles
micelle
physicochemical properties
tumor microenvironment
Issue Date: Aug-2012
Source: Li, W., Feng, S., Guo, Y. (2012-08). Tailoring polymeric micelles to optimize delivery to solid tumors. Nanomedicine 7 (8) : 1235-1252. ScholarBank@NUS Repository. https://doi.org/10.2217/nnm.12.88
Abstract: Block copolymer micelles have shown great potential in drug delivery systems, not only for overcoming the drawbacks of small agents such as water insolubility and wide distribution in normal tissues, but also for avoiding traditional nanoparticle formulation shortcomings, including in vivo instability and fast clearance from the blood. However, for translating micellar formulations to clinical practice, it is essential to overcome the many in vivo obstacles. Surmounting these barriers strongly depends on micellar physicochemical properties, which can be further optimized by the unique physiological aspects of solid tumors such as low pH, high temperature and the presence of abnormal vessels. Herein, based on the Flory parameter and scaling theory, the fundamental mechanisms and correlations in vitro/in vivo between self assembly, drug loading and release, stability, intracellular delivery and in vivo distribution, as well as micellar composition, size and microstructural tailoring are systematically revisited. The methods for enhancing micellar performance in solid tumors were consequently proposed through well-defined core-corona structure tailoring. © 2012 Future Medicine Ltd.
Source Title: Nanomedicine
URI: http://scholarbank.nus.edu.sg/handle/10635/68436
ISSN: 17435889
DOI: 10.2217/nnm.12.88
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