Please use this identifier to cite or link to this item:
Title: Temporal variations of the cell-free layer width may enhance NO bioavailability in small arterioles: Effects of erythrocyte aggregation
Authors: Ong, P.K.
Jain, S.
Kim, S. 
Keywords: Microcirculation
Nitric oxide
Wall shear stress
Issue Date: May-2011
Citation: Ong, P.K., Jain, S., Kim, S. (2011-05). Temporal variations of the cell-free layer width may enhance NO bioavailability in small arterioles: Effects of erythrocyte aggregation. Microvascular Research 81 (3) : 303-312. ScholarBank@NUS Repository.
Abstract: Recently, we have shown that temporal variations in the cell-free layer width can potentially enhance nitric oxide (NO) bioavailability in small arterioles. Since the layer width variations can be augmented by red blood cell aggregation, we tested the hypothesis that an increase in the layer width variations due to red blood cell aggregation could provide an underlying mechanism to improve NO bioavailability in the endothelium and promote vasodilatory effects. Utilizing cell-free layer width data acquired from arterioles of the rat cremaster muscle before and after dextran infusion in reduced flow conditions (wall shear stress = 0.13-0.24. Pa), our computational model predicted exponential enhancements of NO bioavailability in the endothelium and soluble guanylyl cyclase (sGC) activation in the smooth muscle layer with increasing temporal variability of the layer width. These effects were mediated primarily by the transient responses of wall shear stress and NO production rate to the layer width variations. The temporal variations in the layer width were significantly enhanced (P<0.05) by aggregation, leading to significant improvements (P<0.05) in NO bioavailability and sGC activation. As a result, the significant reduction (P<0.05) of sGC activation due to the increased width of the layer after aggregation induction was diminished by the opposing effect of the layer variations. These findings highlighted the possible enhancement of NO bioavailability and vascular tone in the arteriole by the augmented layer width variations due to the aggregation. © 2011 Elsevier Inc.
Source Title: Microvascular Research
ISSN: 00262862
DOI: 10.1016/j.mvr.2011.02.002
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Mar 17, 2019


checked on Mar 6, 2019

Page view(s)

checked on Mar 16, 2019

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.