Please use this identifier to cite or link to this item: https://doi.org/10.1002/jbm.a.31906
Title: Supramolecular hydrogels based on self-assembly between PEO-PPO-PEO triblock copolymers and α-cyclodextrin
Authors: Ni, X.
Cheng, A.
Li, J. 
Keywords: Cyclodextrin
Hydrogel
Poly (propylene oxide)
Poly(ethylene oxide)
Self-assembly
Supramolecule
Triblock copolymer
Issue Date: 15-Mar-2009
Source: Ni, X., Cheng, A., Li, J. (2009-03-15). Supramolecular hydrogels based on self-assembly between PEO-PPO-PEO triblock copolymers and α-cyclodextrin. Journal of Biomedical Materials Research - Part A 88 (4) : 1031-1036. ScholarBank@NUS Repository. https://doi.org/10.1002/jbm.a.31906
Abstract: This article reports a detailed study on the hydrogel formation of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers with α-cyclodextrin (α-CD) in aqueous solutions. The gelation kinetics and the gel rheological properties were studied using viscometry. The sol-gel phase transitions were studied using phase diagrams, while the gelation mechanism was studied using differential scanning calorimetric analysis. It was concluded that the gelation was induced by the complex formation between the PEO segments of the PEO-PPO-PEO triblock copolymer and α-CD, and the further self-assembly of the partially formed inclusion complexes. The addition of α-CD largely reduced the concentration of the copolymer needed for gel formation. The gels were thixotropic and reversible, and potentially suitable for use as an injectable drug-delivery system. © 2008 Wiley Periodicals, Inc.
Source Title: Journal of Biomedical Materials Research - Part A
URI: http://scholarbank.nus.edu.sg/handle/10635/67291
ISSN: 15493296
DOI: 10.1002/jbm.a.31906
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

49
checked on Dec 7, 2017

WEB OF SCIENCETM
Citations

49
checked on Nov 22, 2017

Page view(s)

30
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.