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|Title:||Supramolecular hydrogels based on self-assembly between PEO-PPO-PEO triblock copolymers and α-cyclodextrin|
Poly (propylene oxide)
|Citation:||Ni, X., Cheng, A., Li, J. (2009-03-15). Supramolecular hydrogels based on self-assembly between PEO-PPO-PEO triblock copolymers and α-cyclodextrin. Journal of Biomedical Materials Research - Part A 88 (4) : 1031-1036. ScholarBank@NUS Repository. https://doi.org/10.1002/jbm.a.31906|
|Abstract:||This article reports a detailed study on the hydrogel formation of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers with α-cyclodextrin (α-CD) in aqueous solutions. The gelation kinetics and the gel rheological properties were studied using viscometry. The sol-gel phase transitions were studied using phase diagrams, while the gelation mechanism was studied using differential scanning calorimetric analysis. It was concluded that the gelation was induced by the complex formation between the PEO segments of the PEO-PPO-PEO triblock copolymer and α-CD, and the further self-assembly of the partially formed inclusion complexes. The addition of α-CD largely reduced the concentration of the copolymer needed for gel formation. The gels were thixotropic and reversible, and potentially suitable for use as an injectable drug-delivery system. © 2008 Wiley Periodicals, Inc.|
|Source Title:||Journal of Biomedical Materials Research - Part A|
|Appears in Collections:||Staff Publications|
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