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Title: Molecular mechanistic insights into the endothelial receptor mediated cytoadherence of Plasmodium falciparum-infected erythrocytes
Authors: Li, A.
Lim, T.S.
Shi, H.
Yin, J.
Tan, S.J.
Li, Z. 
Low, B.C. 
Tan, K.S.W.
Lim, C.T. 
Issue Date: 2011
Source: Li, A.,Lim, T.S.,Shi, H.,Yin, J.,Tan, S.J.,Li, Z.,Low, B.C.,Tan, K.S.W.,Lim, C.T. (2011). Molecular mechanistic insights into the endothelial receptor mediated cytoadherence of Plasmodium falciparum-infected erythrocytes. PLoS ONE 6 (3) : -. ScholarBank@NUS Repository.
Abstract: Cytoadherence or sequestration is essential for the pathogenesis of the most virulent human malaria species, Plasmodium falciparum (P. falciparum). Similar to leukocyte-endothelium interaction in response to inflammation, cytoadherence of P. falciparum infected red blood cells (IRBCs) to endothelium occurs under physiological shear stresses in blood vessels and involves an array of molecule complexes which cooperate to form stable binding. Here, we applied single-molecule force spectroscopy technique to quantify the dynamic force spectra and characterize the intrinsic kinetic parameters for specific ligand-receptor interactions involving two endothelial receptor proteins: thrombospondin (TSP) and CD36. It was shown that CD36 mediated interaction was much more stable than that mediated by TSP at single molecule level, although TSP-IRBC interaction appeared stronger than CD36-IRBC interaction in the high pulling rate regime. This suggests that TSP-mediated interaction may initiate cell adhesion by capturing the fast flowing IRBCs whereas CD36 functions as the 'holder' for providing stable binding. © 2011 Li et al.
Source Title: PLoS ONE
ISSN: 19326203
DOI: 10.1371/journal.pone.0016929
Appears in Collections:Staff Publications

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