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|Title:||In Vivo Efficacy of Bone-Marrow-Coated Polycaprolactone Scaffolds for the Reconstruction of Orbital Defects in the Pig|
Fused deposition modeling
|Source:||Rohner, D.,Hutmacher, D.W.,Cheng, T.K.,Oberholzer, M.,Hammer, B. (2003-08-15). In Vivo Efficacy of Bone-Marrow-Coated Polycaprolactone Scaffolds for the Reconstruction of Orbital Defects in the Pig. Journal of Biomedical Materials Research - Part B Applied Biomaterials 66 (2) : 574-580. ScholarBank@NUS Repository.|
|Abstract:||Alloplastic materials offer a number of advantages over bone autografts in the reconstruction of craniofacial defects. These include: lack of donor site morbidity, unlimited quantities of available material, and the possibility to conform exactly to the defect. An ideal bioresorbable material would degrade slowly, and have osteoconductive properties to allow replacement and remodeling by osseous tissue. This is seldom observed, the materials instead being replaced by fibrous tissue. Polycaprolactone (PCL), an FDA-approved bioresorbable polymer, has several properties that might make it suitable for reconstruction of craniofacial defects. The technique of fused deposition modeling (FDM) allows for the fabrication of highly reproducible bioresorbable 3D scaffolds. The nature of the fully interconnected pore network might enhance vascular ingrowth and osteoconductive properties. It was hypothesized that coating the scaffolds in bone marrow might enhance bone formation due to the osteoinductive nature of the bone-marrow mesenchymal cells. This study aimed to test these hypotheses in the pig model. Defects measuring 2 x 2 cm were surgically created in each orbit of eight Yorkshire pigs. The orbits were divided into three groups: Group 1 (n = 4), no reconstruction (control); Group 2 (n = 6), reconstruction with no coated PCL scaffolds; and Group 3 (n = 6) reconstruction with bone-marrow-coated PCL scaffolds. The results were evaluated at 3 months by histological and histomorphometric analyses. The defects in Group 1 were covered with fibrous scar tissue. The shape of the reconstructed area was insufficient. The defects in Groups 2 and 3 were reconstructed correctly. In Group 2 the noncoated scaffolds showed 4.5% of new bone formation compared with 14.1% in Group 3, which is statistically significant (p < 0.05). The entirely interconnected 3D polycaprolactone scaffold seems to be a promising material. It induces the bone ingrowth required for reconstructing craniofacial and orbital defects. Further long-term evaluations of these PCL scaffolds must be made in order to confirm these conclusions. © 2003 Wiley Periodicals, Inc.|
|Source Title:||Journal of Biomedical Materials Research - Part B Applied Biomaterials|
|Appears in Collections:||Staff Publications|
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