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Title: Enabling biomedical research with designer quantum dots
Authors: Tomczak, N.
Jańczewski, D.
Dorokhin, D.
Han, M.-Y. 
Vancso, G.J.
Keywords: Cell membrane
In vivo imaging
Living cells
Quantum dots
Surface modifi cation
Issue Date: 2012
Citation: Tomczak, N.,Jańczewski, D.,Dorokhin, D.,Han, M.-Y.,Vancso, G.J. (2012). Enabling biomedical research with designer quantum dots. Methods in Molecular Biology 811 : 245-265. ScholarBank@NUS Repository.
Abstract: Quantum Dots (QDs) are a new class of semiconductor nanoparticulate luminophores, which are actively researched for novel applications in biology and nanomedicine. In this review, the recent progress in the design and applications of QD labels for in vitro and in vivo imaging of cells is presented. Surface chemical engineering of hydrophobic QDs is required to render them water soluble and biocompatible. Further surface modification and attachment of bioactive molecules to the surface of QDs, such as peptides, aptamers, or antibodies are intensively explored for targeted imaging of living cells, and disease states in animals. Specially designed surface coatings can drastically decrease nonspecific interactions between QDs and cells, minimize degradation of QDs under in vivo physiological conditions, reduce the cytotoxicity of QDs, and prolong circulation lifetimes in animals. New generations of QD probes are also promising for imaging cellular processes at the single-molecule level. Ultimately, QDs as components of complex therapeutic nanosystems are poised to contribute significantly to the field of personalized medicine. © 2012 Springer Science+Business Media, LLC.
Source Title: Methods in Molecular Biology
ISBN: 9781617793875
ISSN: 10643745
DOI: 10.1007/978-1-61779-388-2_16
Appears in Collections:Staff Publications

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