Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/66645
Title: Kinetic and equilibrium study of the enantioseparation of fluoxetine on a new β-cyclodextrin column by high performance liquid chromatography
Authors: Yu, H.W.
Ching, C.B. 
Keywords: β-Cyclodextrin chiral stationary phase
Column liquid chromatography
Fluoxetine
Kinetic and equilibrium constants
Issue Date: 2001
Source: Yu, H.W.,Ching, C.B. (2001). Kinetic and equilibrium study of the enantioseparation of fluoxetine on a new β-cyclodextrin column by high performance liquid chromatography. Chromatographia 54 (11-12) : 697-702. ScholarBank@NUS Repository.
Abstract: A new β-cyclodextrin preparative chiral stationary phase was developed and utilized to separate racemic fluoxetine by high performance liquid chromatography. Kinetic and equilibrium constants for the chromatographic enantioseparation of racemic fluoxetine, using water and buffer (TTAA) as the mobile phase, were evaluated by moment analysis on the basis of equilibrium-dispersive and linear driving force models. Other parameters, including the voidage of the column and the axial dispersion coefficient, were also determined. The parameters obtained were used in the simulation of two single enantiomer band profiles. It was found that the experimental and simulated results match quite well confirming that the parameters used in simulation were correct.
Source Title: Chromatographia
URI: http://scholarbank.nus.edu.sg/handle/10635/66645
ISSN: 00095893
Appears in Collections:Staff Publications

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