Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0928-4931(02)00018-8
Title: Cellulose acetate membranes for transdermal delivery of scopolamine base
Authors: Wang, F.-J.
Yang, Y.-Y.
Zhang, X.-Z.
Zhu, X.
Chung, T.-S. 
Moochhala, S.
Keywords: Cellulose acetate membranes
Polyethylene glycol (PEG)
Scopolamine
Transdermal delivery
Issue Date: 31-May-2002
Source: Wang, F.-J., Yang, Y.-Y., Zhang, X.-Z., Zhu, X., Chung, T.-S., Moochhala, S. (2002-05-31). Cellulose acetate membranes for transdermal delivery of scopolamine base. Materials Science and Engineering C 20 (1-2) : 93-100. ScholarBank@NUS Repository. https://doi.org/10.1016/S0928-4931(02)00018-8
Abstract: Transdermal delivery is one of the most convenient drug administration routes. In this study, the cellulose acetate membranes were cast with acetone as a solvent at 22 and 40 °C. Polyethylene glycol (PEG, MW 600) was used as a pore-forming agent. The in vitro release rates of scopolamine base as a model drug through the membranes were evaluated in phosphate buffer solution (PBS, pH 7.4) at 32 °C. The membranes were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), thermal mechanical analysis (TMA) and thermogravimetric analysis (TGA). It was observed that the drug permeation through the cellulose acetate membranes was obviously affected by the incorporated PEG content and formed membrane morphology. There was no drug flux from the cellulose acetate membranes prepared without PEG. An increased PEG content resulted in a faster scopolamine release due to a more porous structure created. Both the membrane fabrication temperature and the PEG content can affect the thermal, mechanical and morphological properties of the resultant membranes. With the optimized fabrication conditions, linear in vitro release profiles of scopolamine over 3 days were achieved. The membranes developed would be useful for transdermal delivery of drugs. © 2002 Elsevier Science B.V. All rights reserved.
Source Title: Materials Science and Engineering C
URI: http://scholarbank.nus.edu.sg/handle/10635/66483
ISSN: 09284931
DOI: 10.1016/S0928-4931(02)00018-8
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

36
checked on Dec 6, 2017

WEB OF SCIENCETM
Citations

36
checked on Nov 21, 2017

Page view(s)

39
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.