Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2011.09.037
Title: Silica-shell cross-linked micelles encapsulating fluorescent conjugated polymers for targeted cellular imaging
Authors: Tan, H. 
Zhang, Y. 
Wang, M.
Zhang, Z.
Zhang, X.
Yong, A.M.
Wong, S.Y.
Chang, A.Y.C.
Chen, Z.-K.
Li, X.
Choolani, M.
Wang, J. 
Keywords: Biomimetic materials
Image analysis
Micelle
Silica
Issue Date: Jan-2012
Source: Tan, H.,Zhang, Y.,Wang, M.,Zhang, Z.,Zhang, X.,Yong, A.M.,Wong, S.Y.,Chang, A.Y.C.,Chen, Z.-K.,Li, X.,Choolani, M.,Wang, J. (2012-01). Silica-shell cross-linked micelles encapsulating fluorescent conjugated polymers for targeted cellular imaging. Biomaterials 33 (1) : 237-246. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2011.09.037
Abstract: A bioinspired silification approach was successfully used to encapsulate fluorescent conjugated polymers inside silica-shell cross-linked polymeric micelles (CP-SSCL) in the highly benign synthesis environment of room temperature and near-neutral aqueous environment. Four different conjugated polymers were employed to demonstrate the versatility of the bioinspired silification, resulting in the formation of CP-SSCL with different emission wavelengths across the visible spectrum. The CP-SSCL are characterized by a large absorption coefficient and high quantum yield, indicating that they exhibit the required high fluorescence brightness for cellular imaging application. In addition, the CP-SSCL also exhibit a high colloidal stability and low cytotoxicity. The in vitro studies of using MDA-MB-231 breast cancer cells show that the CP-SSCL are successfully uptaken by the cancer cells and located at the cytoplasm of the cells. Furthermore, by conjugating folic acid on their surfaces, the uptake of CP-SSCL by MDA-MB-231 cells was enhanced significantly, suggesting their great potential for targeted imaging and early detection of cancer cells. © 2011 Elsevier Ltd.
Source Title: Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/64997
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2011.09.037
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