Please use this identifier to cite or link to this item:
|Title:||Computational modeling for cell spreading on a substrate mediated by specific interactions, long-range recruiting interactions, and diffusion of binders|
|Citation:||Sun, L., Cheng, Q.H., Gao, H.J., Zhang, Y.-W. (2009-06-05). Computational modeling for cell spreading on a substrate mediated by specific interactions, long-range recruiting interactions, and diffusion of binders. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 79 (6) : -. ScholarBank@NUS Repository. https://doi.org/10.1103/PhysRevE.79.061907|
|Abstract:||A continuum model was proposed to study cell spreading on a flat substrate mediated by specific interaction, long-range recruiting interaction, and the diffusion of binders. Specific interactions between the mobile receptors embedded in the cell membrane and ligands coated on the substrate surface result in cell adhesion to the substrate surface. This receptor-ligand interaction was described by a chemical reaction equation. Long-range recruiting interactions between the receptors and the substrate were simplified by a traction-separation law. The governing equations and boundary conditions were formulated for the entire process of cell spreading and solved using a finite element scheme. Parametric studies were conducted to investigate the effect of system parameters on the cell spreading kinetics. It is shown that kinetic factors play an important role in cell adhesion and three regimes, that is, the binder reaction limited regime, long-range recruiting force-driven binder recruitment limited regime, and the concentration gradient-driven diffusion limited regime, were identified. © 2009 The American Physical Society.|
|Source Title:||Physical Review E - Statistical, Nonlinear, and Soft Matter Physics|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jul 17, 2018
WEB OF SCIENCETM
checked on Jun 27, 2018
checked on Mar 11, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.