Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/64716
Title: The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for Gram-positive bacteria over erythrocytes
Authors: Liu, L.
Yang, J.
Xie, J. 
Luo, Z.
Jiang, J.
Yang, Y.Y.
Liu, S.
Issue Date: 7-May-2013
Citation: Liu, L., Yang, J., Xie, J., Luo, Z., Jiang, J., Yang, Y.Y., Liu, S. (2013-05-07). The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for Gram-positive bacteria over erythrocytes. Nanoscale 5 (9) : 3834-3840. ScholarBank@NUS Repository.
Abstract: Silver nanoparticles are of great interest for use as antimicrobial agents. Studies aimed at producing potent nano-silver biocides have focused on manipulation of particle size, shape, composition and surface charge. Here, we report the cell penetrating peptide catalyzed formation of antimicrobial silver nanoparticles in N,N-dimethylformamide. The novel nano-composite demonstrated a distinctly enhanced biocidal effect toward bacteria (Gram-positive Bacillus subtilis, Gram-negative Escherichia coli) and pathogenic yeast (Candida albicans), as compared to triangular and extremely small silver nanoparticles. In addition, a satisfactory biocompatibility was verified by a haemolysis test. Our results provide a paradigm in developing strategies that can maximize the silver nanoparticle application potentials while minimizing the toxic effects. © 2013 The Royal Society of Chemistry.
Source Title: Nanoscale
URI: http://scholarbank.nus.edu.sg/handle/10635/64716
ISSN: 20403364
Appears in Collections:Staff Publications

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