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https://scholarbank.nus.edu.sg/handle/10635/64716
Title: | The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for Gram-positive bacteria over erythrocytes | Authors: | Liu, L. Yang, J. Xie, J. Luo, Z. Jiang, J. Yang, Y.Y. Liu, S. |
Issue Date: | 7-May-2013 | Citation: | Liu, L., Yang, J., Xie, J., Luo, Z., Jiang, J., Yang, Y.Y., Liu, S. (2013-05-07). The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for Gram-positive bacteria over erythrocytes. Nanoscale 5 (9) : 3834-3840. ScholarBank@NUS Repository. | Abstract: | Silver nanoparticles are of great interest for use as antimicrobial agents. Studies aimed at producing potent nano-silver biocides have focused on manipulation of particle size, shape, composition and surface charge. Here, we report the cell penetrating peptide catalyzed formation of antimicrobial silver nanoparticles in N,N-dimethylformamide. The novel nano-composite demonstrated a distinctly enhanced biocidal effect toward bacteria (Gram-positive Bacillus subtilis, Gram-negative Escherichia coli) and pathogenic yeast (Candida albicans), as compared to triangular and extremely small silver nanoparticles. In addition, a satisfactory biocompatibility was verified by a haemolysis test. Our results provide a paradigm in developing strategies that can maximize the silver nanoparticle application potentials while minimizing the toxic effects. © 2013 The Royal Society of Chemistry. | Source Title: | Nanoscale | URI: | http://scholarbank.nus.edu.sg/handle/10635/64716 | ISSN: | 20403364 |
Appears in Collections: | Staff Publications |
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