Please use this identifier to cite or link to this item:
Title: Surface modification of silicone for biomedical applications requiring long-term antibacterial, antifouling, and hemocompatible properties
Authors: Li, M.
Neoh, K.G. 
Xu, L.Q.
Wang, R.
Kang, E.-T. 
Lau, T.
Olszyna, D.P.
Chiong, E.
Issue Date: 27-Nov-2012
Source: Li, M., Neoh, K.G., Xu, L.Q., Wang, R., Kang, E.-T., Lau, T., Olszyna, D.P., Chiong, E. (2012-11-27). Surface modification of silicone for biomedical applications requiring long-term antibacterial, antifouling, and hemocompatible properties. Langmuir 28 (47) : 16408-16422. ScholarBank@NUS Repository.
Abstract: Silicone has been used for peritoneal dialysis (PD) catheters for several decades. However, bacteria, platelets, proteins, and other biomolecules tend to adhere to its hydrophobic surface, which may lead to PD outflow failure, serious infection, or even death. In this work, a cross-linked poly(poly(ethylene glycol) dimethacrylate) (P(PEGDMA)) polymer layer was covalently grafted on medical-grade silicone surface to improve its antibacterial and antifouling properties. The P(PEGDMA)-grafted silicone (Silicone-g-P(PEGDMA)) substrate reduced the adhesion of Staphylococcus aureus, Escherichia coli, and Staphylococcus epidermidis, as well as 3T3 fibroblast cells by ≤90%. The antibacterial and antifouling properties were preserved after the modified substrate was aged for 30 days in phosphate buffer saline. Further immobilization of a polysulfobetaine polymer, poly((2-(methacryloyloxy)ethyl) dimethyl-(3-sulfopropyl)ammonium hydroxide) (P(DMAPS)), on the Silicone-g-P(PEGDMA) substrate via thiol-ene click reaction leads to enhanced antifouling efficacy and improved hemocompatibility with the preservation of the antibacterial property. Compared to pristine silicone, the so-obtained Silicone-g-P(PEGDMA)-P(DMAPS) substrate reduced the absorption of bovine serum albumin and bovine plasma fibrinogen by ≤80%. It also reduced the number of adherent platelets by ≤90% and significantly prolonged plasma recalcification time. The results indicate that surface grafting with P(PEGDMA) and P(DMAPS) can be potentially useful for the modification of silicone-based PD catheters for long-term applications. © 2012 American Chemical Society.
Source Title: Langmuir
ISSN: 07437463
DOI: 10.1021/la303438t
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Mar 14, 2018


checked on Mar 14, 2018

Page view(s)

checked on Mar 11, 2018

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.