Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2011.11.051
Title: Quantitative control of targeting effect of anticancer drugs formulated by ligand-conjugated nanoparticles of biodegradable copolymer blend
Authors: Zhao, J.
Mi, Y.
Liu, Y.
Feng, S.-S. 
Keywords: Biodegradable copolymers
Cancer nanotechnology
Chemotherapeutic engineering
Drug targeting
Herceptin ®
Nanomedicine
Issue Date: Feb-2012
Source: Zhao, J., Mi, Y., Liu, Y., Feng, S.-S. (2012-02). Quantitative control of targeting effect of anticancer drugs formulated by ligand-conjugated nanoparticles of biodegradable copolymer blend. Biomaterials 33 (6) : 1948-1958. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2011.11.051
Abstract: There have been two strategies developed in the recent literature for quantitative control of the targeting effects for drug delivery by ligand-conjugated nanoparticles of biodegradable copolymer blend such as PLGA/PLGA-PEG, i.e. the pre-conjugation strategy and the post-conjugation strategy, in which the ligand conjugation was made before and after the nanoparticle formulation respectively. This research developed another drug delivery system of the PLA-TPGS/TPGS-COOH copolymer blend and further improved the post-conjugation strategy to precisely control the targeting effects by two ways: one is to adjust the PLA-TPGS:TPGS-COOH copolymer blend ratio in the nanoparticle formulation process, which provides a way for coarse control, and another is to control the feeding concentration of the ligand in the herceptin conjugation process, which further provides a fine control. Herceptin conjugation was visualized by the FETEM with immumogold labeling and further quantified by the two techniques, i.e. the Bradford assay and the flow cytometry to confirm each other. The positive correlation between the surface density of the ligand and the cellular internalization as well as the cytotoxicity of the nanoparticle formulations was assessed, which demonstrated that the strategy developed in this research is simple and feasible, which can precisely control the targeting effects of the nanoparticles of biodegradable polymers as well as other nanocarriers such as micelles and liposomes. © 2011 Elsevier Ltd.
Source Title: Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/64482
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2011.11.051
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

43
checked on Dec 7, 2017

WEB OF SCIENCETM
Citations

38
checked on Nov 23, 2017

Page view(s)

23
checked on Dec 11, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.