Please use this identifier to cite or link to this item: https://doi.org/10.1039/c3tb00009e
Title: Preventing viral infections with polymeric virus catchers: A novel nanotechnological approach to anti-viral therapy
Authors: Sankarakumar, N.
Tong, Y.W. 
Issue Date: 21-Apr-2013
Source: Sankarakumar, N., Tong, Y.W. (2013-04-21). Preventing viral infections with polymeric virus catchers: A novel nanotechnological approach to anti-viral therapy. Journal of Materials Chemistry B 1 (15) : 2031-2037. ScholarBank@NUS Repository. https://doi.org/10.1039/c3tb00009e
Abstract: Infectious diseases caused by viruses are among the most vexing medical issues that we are yet to solve, even with billions of dollars being spent on drugs and vaccines to combat and prevent such infections. Finding a cure or vaccine for some of the most common or the most deadly viruses such as the influenza or the Ebola virus has been a daunting task due to their constant mutation and adaptation to our attempts. Existing therapeutics that lose their effectiveness with time due to mutations have brought about the need to consider alternative treatment approaches. To cater to the ever-increasing demand for new antiviral strategies, a novel approach of using high affinity polymeric receptors prepared by a molecular imprinting technique to "catch" viruses is presented. After three hours of mixing with the template virus, a very significant reduction in infectivity titers was observed with the virus imprinted particles. The virucidal action of the imprinted particles was rapid, dose dependent on virus and polymer concentration and occurred due to specific adsorption. The fabricated nanoparticles displayed remarkable positive anti-viral results that significantly hindered viral infections as compared to the controls. This work thus successfully demonstrates the application of miniemulsion polymerization to surface imprinting of viruses and the novel application of such imprinted materials in infectious disease treatment. The findings represent a significant breakthrough in the field of molecular imprinting and antiviral therapy and we anticipate this work to be a starting point for path-breaking research in the near future. This journal is © 2013 The Royal Society of Chemistry.
Source Title: Journal of Materials Chemistry B
URI: http://scholarbank.nus.edu.sg/handle/10635/64468
ISSN: 20507518
DOI: 10.1039/c3tb00009e
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

11
checked on Mar 26, 2018

WEB OF SCIENCETM
Citations

11
checked on Mar 26, 2018

Page view(s)

31
checked on Mar 11, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.