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|Title:||Poly(dopamine acrylamide)-co-poly(propargyl acrylamide)-modified titanium surfaces for 'click' functionalization|
|Citation:||Xu, L.Q., Jiang, H., Neoh, K.-G., Kang, E.-T., Fu, G.D. (2012-04). Poly(dopamine acrylamide)-co-poly(propargyl acrylamide)-modified titanium surfaces for 'click' functionalization. Polymer Chemistry 3 (4) : 920-927. ScholarBank@NUS Repository. https://doi.org/10.1039/c2py00552b|
|Abstract:||Poly(dopamine acrylamide)-co-poly(propargyl acrylamide) (PDA-co-PPA) copolymers, containing alkyne- and catechol-functionalities, were prepared from reactive poly(pentafluorophenyl acrylate) (PPFA) via functionalization of the pentafluorophenyl-activated ester groups with dopamine hydrochloride and propargylamine. The bifunctional PDA-co-PPA copolymers were then coupled to the titanium (Ti) surface via coordination interaction of the catechol moieties, yielding a functionalizable Ti platform containing 'clickable' alkyne groups on the surface for the copper-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) of azide-labeled fluorescein, rhodamine, β-cyclodextrin, poly(ethylene glycol) (PEG), mannose and biotin. The functionalized Ti surfaces from the CuAAC reactions were characterized by fluorescence microscopy (for the rhodamine- and fluorescein-functionalized Ti surfaces), non-specific protein adsorption (for the PEG-grafted Ti surface), specific protein adsorption (for the mannose- and biotin-functionalized Ti surfaces) and host-guest interaction with antibiotics (for the β-cyclodextrin-functionalized Ti surface). © 2012 The Royal Society of Chemistry.|
|Source Title:||Polymer Chemistry|
|Appears in Collections:||Staff Publications|
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