Please use this identifier to cite or link to this item: https://doi.org/10.1002/mabi.201100173
Title: PEGylated anti-MUC1 aptamer-doxorubicin complex for targeted drug delivery to MCF7 breast cancer cells
Authors: Tan, L.
Neoh, K.G. 
Kang, E.-T. 
Choe, W.S.
Su, X.
Keywords: Aptamers
Biological applications of polymers
Breast cancer
Doxorubicin
Drug delivery systems
Issue Date: 10-Oct-2011
Source: Tan, L., Neoh, K.G., Kang, E.-T., Choe, W.S., Su, X. (2011-10-10). PEGylated anti-MUC1 aptamer-doxorubicin complex for targeted drug delivery to MCF7 breast cancer cells. Macromolecular Bioscience 11 (10) : 1331-1335. ScholarBank@NUS Repository. https://doi.org/10.1002/mabi.201100173
Abstract: Targeted drug delivery is especially important in cancer treatment as many anti-cancer drugs are non-specific and highly toxic to both cancer and normal cells. The targeted drug delivery of DOX to the MUC1-expressing breast cancer cell line (MCF7) was obtained using APT as a carrier. Modification of the APT-DOX complex by PEG increases the survivability of the macrophage control (RAW 264.7) by about six-fold as compared to free DOX treatment without significantly affecting the cytotoxicity toward the target cell line. Thus, PEG-APT-DOX is potentially a new therapeutic agent for targeted drug delivery to MUC1-expressing cell lines. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Macromolecular Bioscience
URI: http://scholarbank.nus.edu.sg/handle/10635/64381
ISSN: 16165187
DOI: 10.1002/mabi.201100173
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