Please use this identifier to cite or link to this item:
|Title:||In situ determination of metastable zone width using dielectric constant measurement|
|Source:||He, G., Tjahjono, M., Chow, P.S., Tan, R.B.H., Garland, M. (2010-11-19). In situ determination of metastable zone width using dielectric constant measurement. Organic Process Research and Development 14 (6) : 1469-1472. ScholarBank@NUS Repository. https://doi.org/10.1021/op100182s|
|Abstract:||This study demonstrates the first use of a dielectric constant meter, coupled with an automated data logging module, for in situ monitoring of solution crystallization processes. The results show that this in situ measurement could detect not only the cloud point that corresponds to the onset of nucleation but also the clear point that closely represents the solubility limit. The metastable zone width (MZW) can subsequently be estimated as the gap between the loci of the cloud and clear points. In addition, the general phenomena of the crystallization process could be observed from several different regions of the dielectric constant profile. Direct comparison with turbidity measurement and focused beam reflectance measurement (FBRM) confirms that the cloud and clear points determined by the present dielectric constant measurement are reliable. This study opens new opportunities for the use of the dielectric constant meter as a simple, inexpensive, and convenient alternative tool in the field of crystallization process monitoring. © 2010 American Chemical Society.|
|Source Title:||Organic Process Research and Development|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Dec 14, 2017
WEB OF SCIENCETM
checked on Nov 17, 2017
checked on Dec 10, 2017
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.