Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jconrel.2004.10.011
Title: Fabrication of monodispersed Taxol-loaded particles using electrohydrodynamic atomization
Authors: Ding, L.
Lee, T.
Wang, C.-H. 
Keywords: Electrohydrodynamic atomization
Monodisperse
Phase Doppler particle analyzer
Poly-caprolactone
Taxol
Issue Date: 2-Feb-2005
Source: Ding, L., Lee, T., Wang, C.-H. (2005-02-02). Fabrication of monodispersed Taxol-loaded particles using electrohydrodynamic atomization. Journal of Controlled Release 102 (2) : 395-413. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jconrel.2004.10.011
Abstract: In the fabrication of controlled drug release matrix, monodispersed particle sizes are usually preferred as they give a more uniform and precisely controlled release profile. Electrohydrodynamic atomization (EHDA) [J.C. Ijsebaert, K.B. Geerse, J.C.M. Marijnissen, J.W.J Lammers, P. Zannen, Electro-Hydrodynamic atomization of drug solutions for inhalation purposes, J. Appl. Physiol. 91(2001), 2735-2741.] is a method that can potentially produce particles with very low polydispersity. In the present work, Taxol-loaded poly-caprolactone (PCL) particles were fabricated using EHDA. Effort was undertaken to investigate the cause of the low yield of EHDA and to improve it to around 80%. This was achieved by increasing the ventilation and properly discharging the residual charges on the particulate cake at the filter paper. A phase Doppler particle analyzer (PDPA) was used to detect the spray modes of EHDA and the optimum operating conditions were determined. With differential scanning calorimetry (DSC), the uniformity of drug and polymer matrix is investigated. Moderate zeta potential values together with laser confocal micrographs give a possible explanation for the in vitro cell uptake data. These results are substantiated by a reasonably high encapsulation efficiency (EE) and sustained release profiles over 1-month period. The EHDA method is shown to be a potentially suitable technique to prepare close to monodispersed drug release particles. © 2004 Elsevier B.V. All rights reserved.
Source Title: Journal of Controlled Release
URI: http://scholarbank.nus.edu.sg/handle/10635/63909
ISSN: 01683659
DOI: 10.1016/j.jconrel.2004.10.011
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

100
checked on Dec 14, 2017

WEB OF SCIENCETM
Citations

98
checked on Nov 17, 2017

Page view(s)

29
checked on Dec 17, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.