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|Title:||Efficient epoxidation of alkenes with hydrogen peroxide, lactone, and lipase|
|Authors:||Xu, Y. |
|Source:||Xu, Y., Khaw, N.R.B.J., Li, Z. (2009). Efficient epoxidation of alkenes with hydrogen peroxide, lactone, and lipase. Green Chemistry 11 (12) : 2047-2051. ScholarBank@NUS Repository. https://doi.org/10.1039/b913077b|
|Abstract:||A green and efficient oxidation system containing hydrogen peroxide, lactone, and lipase was developed for the epoxidation of alkenes. A variety of alkenes was oxidized with this system, giving 87-95% analytical yield of the corresponding epoxides. The epoxidation occurred via lipase-catalyzed formation of hydroxy peroxy acid from lactone, without release of any harmful short-chain acid and alcohol, and in situ chemical oxidation of alkenes. Both hydrophilic ε-caprolactone and hydrophobic δ-decanolactone were shown to be good substrates to produce hydroxy peracids and good reaction solvents, and the method is suitable for the oxidation in either single phase or two-liquid phase. In comparison with other lipase-mediated oxidation systems, the new oxidation system gave higher yield, higher efficiency, and higher enzyme stability. © 2009 The Royal Society of Chemistry.|
|Source Title:||Green Chemistry|
|Appears in Collections:||Staff Publications|
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