Please use this identifier to cite or link to this item: https://doi.org/10.1002/jbm.a.32867
Title: Core/shell microspheres via coaxial electrohydrodynamic atomization for sequential and parallel release of drugs
Authors: Nie, H. 
Dong, Z.
Arifin, D.Y. 
Hu, Y.
Wang, C.-H. 
Keywords: Coaxial electrohydrodynamic atomization
Core/shell microspheres
Drug delivery
Parallel release
Sequential release
Issue Date: 1-Dec-2010
Source: Nie, H., Dong, Z., Arifin, D.Y., Hu, Y., Wang, C.-H. (2010-12-01). Core/shell microspheres via coaxial electrohydrodynamic atomization for sequential and parallel release of drugs. Journal of Biomedical Materials Research - Part A 95 (3 A) : 709-716. ScholarBank@NUS Repository. https://doi.org/10.1002/jbm.a.32867
Abstract: Herein, it is demonstrated that coaxial electrohydrodynamic atomization can be used for the fabrication of microspheres with distinct core/shell structure. This allows the encapsulation of two different types of drugs in different compartments in one single step. In Group A, we prepared microspheres in which the core and the shell contain hydrophobic and hydrophilic drugs, respectively. In contrast, in Group B, the opposite is prepared. While the former can be achieved by using amphiphilic polymers in aqueous environment, the latter is difficult to be prepared. The release patterns of the two groups are significantly different. The release of drugs from Group A microspheres is rather sequential, whereas group B microspheres release drugs in a parallel (co-release) manner. Nevertheless, in both groups, we found that the release of drugs can be easily tailored by altering outer/inner flow ratios. These findings present the advantages and possible application of this multi-drug release system in chemotherapy. Moreover, cell culture experiments have been performed to testify the performances of different microspheres in cytotoxicity and cellular apoptosis in vitro. © 2010 Wiley Periodicals, Inc.
Source Title: Journal of Biomedical Materials Research - Part A
URI: http://scholarbank.nus.edu.sg/handle/10635/63672
ISSN: 15493296
DOI: 10.1002/jbm.a.32867
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