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Title: Synthesis and characterization of silver/silicon-cosubstituted nanohydroxyapatite
Authors: Lim, P.N.
Tay, B.Y.
Chan, C.M.
Thian, E.S. 
Keywords: cosubstitution
Issue Date: Jan-2012
Citation: Lim, P.N., Tay, B.Y., Chan, C.M., Thian, E.S. (2012-01). Synthesis and characterization of silver/silicon-cosubstituted nanohydroxyapatite. Journal of Biomedical Materials Research - Part B Applied Biomaterials 100 B (1) : 285-291. ScholarBank@NUS Repository.
Abstract: Favorable cell-material interaction and the absence of undesirable reaction from the host body defence system play a critical role in determining the success and long-term survival of the implants. Substitution of various elements into hydroxyapatite (HA) has been done to alter its chemical composition, thereby mimicking that of the bone mineral. In this study, a cosubstituted nanosized apatite (Ag/Si-HA) containing Ag (0.3 wt %) and Si (0.8 wt %) was synthesized by an aqueous precipitation technique. The synthesized Ag/Si-HA displayed a rod-like morphology of dimensions ∼50 nm in length and ∼15 nm in width, as observed from the transmission electron microscope image. With an increase in temperature, the aspect ratio of nanosized Ag/Si-HA decreased, whilst the size increased. Autoclaving was used to achieve sufficient crystallinity while maintaining the rod-like morphology and size that were comparable to that of the bone apatite. A pure Ag/Si-HA was produced without any undesirable secondary phases, as evidenced from the X-ray diffraction and thermal gravimetric results. The Ag/Si cosubstitution affected the lattice cell parameters, in particularly the a- and c- axes which further led to an expansion of the unit cell volume. In addition, the relative intensity of the hydroxyl vibrational bands was reduced. These results demonstrated that a stable phase-pure Ag/Si-HA was produced using an aqueous precipitation reaction. © 2011 Wiley Periodicals, Inc.
Source Title: Journal of Biomedical Materials Research - Part B Applied Biomaterials
ISSN: 15524973
DOI: 10.1002/jbm.b.31951
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