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|Title:||Role of silver ions in destabilization of intermolecular adhesion forces measured by atomic force microscopy in Staphylococcus epidermidis biofilms|
|Citation:||Chaw, K.C., Manimaran, M., Tay, F.E.H. (2005-12). Role of silver ions in destabilization of intermolecular adhesion forces measured by atomic force microscopy in Staphylococcus epidermidis biofilms. Antimicrobial Agents and Chemotherapy 49 (12) : 4853-4859. ScholarBank@NUS Repository. https://doi.org/10.1128/AAC.49.12.4853-4859.2005|
|Abstract:||In this paper, we report on the potential use of atomic force microscopy (AFM) as a tool to measure the intermolecular forces in biofilm structures and to study the effect of silver ions on sessile Staphylococcus epidermidis cell viability and stability. We propose a strategy of destabilizing the biofilm matrix by reducing the intermolecular forces within the extracellular polymeric substances (EPSs) using a low concentration (50 ppb) of silver ions. Our AFM studies on the intermolecular forces within the EPSs of S. epidermidis RP62A and S. epidermidis 1457 biofilms suggest that the silver ions can destabilize the biofilm matrix by binding to electron donor groups of the biological molecules. This leads to reductions in the number of binding sites for hydrogen bonds and electrostatic and hydrophobic interactions and, hence, the destabilization of the biofilm structure. Copyright © 2005, American Society for Microbiology. All Rights Reserved.|
|Source Title:||Antimicrobial Agents and Chemotherapy|
|Appears in Collections:||Staff Publications|
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