Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jmbbm.2008.01.007
Title: Processing nanoengineered scaffolds through electrospinning and mineralization suitable for biomimetic bone tissue engineering
Authors: Liao, S. 
Murugan, R.
Chan, C.K. 
Ramakrishna, S. 
Keywords: Bone scaffolds
Electrospinning
Hydroxyapatite
Mineralization
Nanofibers
Issue Date: Jul-2008
Source: Liao, S.,Murugan, R.,Chan, C.K.,Ramakrishna, S. (2008-07). Processing nanoengineered scaffolds through electrospinning and mineralization suitable for biomimetic bone tissue engineering. Journal of the Mechanical Behavior of Biomedical Materials 1 (3) : 252-260. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jmbbm.2008.01.007
Abstract: Processing scaffolds that mimic the extracellular matrix (ECM) of natural bone in structure and chemical composition is a potential promising option for engineering physiologically functional bone tissue. In this article, we report a novel method, by combining electrospinning and mineralization, to process a series of nano-fibrous scaffolding systems with desirable characteristics suitable for biomimetic bone tissue engineering. We have chosen two types of polymers, namely collagen and poly (lactic-co-glycolic acid) (PLGA), natural and synthetic of its kind, respectively, to electrospin into nano-fibrous scaffolds. The electrospun scaffolds have high surface area, high porosity and well connected open pore network. In order to mimic the chemical composition of native bone ECM, the electrospun scaffolds were subjected to mineralization under optimal conditions. From the experimental results, we observed that the formation of bone-like apatite into collagen was relatively abundant and significantly more uniform than PLGA. The major finding of this study has suggested that the surface functional groups of the scaffolding material, such as carboxyl and carbonyl groups of collagen, are important for the mineralization in vitro. In addition, this study revealed that the mineralization process predominantly induce the formation of nanosize carbonated hydroxyapatite (CHA) during collagen mineralization, whilst nanosize hydroxyapatite (HA) is formed during PLGA mineralization. These findings are critically important while selecting the material for processing bone scaffolding system. © 2008 Elsevier Ltd. All rights reserved.
Source Title: Journal of the Mechanical Behavior of Biomedical Materials
URI: http://scholarbank.nus.edu.sg/handle/10635/61154
ISSN: 17516161
DOI: 10.1016/j.jmbbm.2008.01.007
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

84
checked on Dec 12, 2017

WEB OF SCIENCETM
Citations

76
checked on Nov 6, 2017

Page view(s)

40
checked on Dec 9, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.