Please use this identifier to cite or link to this item:
|Title:||Polysaccharide nanofibrous scaffolds as a model for in vitro skin tissue regeneration|
|Citation:||Krishnan, R., Rajeswari, R., Venugopal, J., Sundarrajan, S., Sridhar, R., Shayanti, M., Ramakrishna, S. (2012-06). Polysaccharide nanofibrous scaffolds as a model for in vitro skin tissue regeneration. Journal of Materials Science: Materials in Medicine 23 (6) : 1511-1519. ScholarBank@NUS Repository. https://doi.org/10.1007/s10856-012-4630-6|
|Abstract:||Tissue engineering and nanotechnology have advanced a general strategy combining the cellular elements of living tissue with sophisticated functional biocomposites to produce living structures of sufficient size and function at a low cost for clinical relevance. Xylan, a natural polysaccharide was electrospun along with polyvinyl alcohol (PVA) to produce Xylan/PVA nanofibers for skin tissue engineering. The Xylan/PVA glutaraldehyde (Glu) vapor cross-linked nanofibers were characterized by SEM, FT-IR, tensile testing and water contact angle measurements to analyze the morphology, functional groups, mechanical properties and wettability of the fibers for skin tissue regeneration. The cell-biomaterial interactions were studied by culturing human foreskin fibroblasts on Xylan/ PVA Glu vapor cross-linked and Xylan/PVA/Glu blend nanofibrous scaffolds. The observed results showed that the mechanical properties (72 %) and fibroblast proliferation significantly increased up to 23 % (P < 0.05) in 48 h Glu vapor cross-linked nanofibers compared to 24 h Glu vapor cross-linked Xylan/PVA nanofibers. The present study may prove that the natural biodegradable Xylan/PVA nanofibrous scaffolds have good potential for fibroblast adhesion, proliferation and cell matrix interactions relevant for skin tissue regeneration. © Springer Science+Business Media, LLC 2012.|
|Source Title:||Journal of Materials Science: Materials in Medicine|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 14, 2019
WEB OF SCIENCETM
checked on Feb 5, 2019
checked on Dec 15, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.