Please use this identifier to cite or link to this item: https://doi.org/10.1002/mabi.201200391
Title: Mimicking Native Extracellular Matrix with Phytic Acid-Crosslinked Protein Nanofibers for Cardiac Tissue Engineering
Authors: Ravichandran, R.
Seitz, V.
Reddy Venugopal, J. 
Sridhar, R.
Sundarrajan, S. 
Mukherjee, S.
Wintermantel, E.
Ramakrishna, S. 
Keywords: Cardiogenic differentiation
Crosslinkers
Ischemic myocardium
Mesenchymal stem cells
Phytic acid
Issue Date: Mar-2013
Source: Ravichandran, R., Seitz, V., Reddy Venugopal, J., Sridhar, R., Sundarrajan, S., Mukherjee, S., Wintermantel, E., Ramakrishna, S. (2013-03). Mimicking Native Extracellular Matrix with Phytic Acid-Crosslinked Protein Nanofibers for Cardiac Tissue Engineering. Macromolecular Bioscience 13 (3) : 366-375. ScholarBank@NUS Repository. https://doi.org/10.1002/mabi.201200391
Abstract: A functional scaffold fabricated is developed from natural polymers, favoring regeneration of the ischemic myocardium. Hemoglobin/gelatin/fibrinogen (Hb/gel/fib) nanofibers are fabricated by electrospinning and are characterized for morphology, scaffold composition, functional groups and hydrophilicity. It is hypothesized that ex vivo pretreatment of mesenchymal stem cells (MSCs) using 5-azacytidine and such a functional nanofibrous construct having a high oxygen-carrying potential could lead to enhanced cardiomyogenic differentiation of MSCs and result in superior biological and functional effects. The combination of a functional nanofibrous scaffold composed of natural polymers and crosslinked with a natural crosslinking agent, phytic acid, and stem cell biology may prove to be a novel therapeutic device for treatment of myocardial infarction. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Macromolecular Bioscience
URI: http://scholarbank.nus.edu.sg/handle/10635/60768
ISSN: 16165187
DOI: 10.1002/mabi.201200391
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

27
checked on Feb 20, 2018

WEB OF SCIENCETM
Citations

27
checked on Feb 20, 2018

Page view(s)

52
checked on Feb 17, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.