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Title: Electrospray deposition of nanohydroxyapatite coatings: A strategy to mimic bone apatite mineral
Authors: Thian, E.S. 
Li, X.
Huang, J.
Edirisinghe, M.J.
Bonfield, W.
Best, S.M.
Keywords: Bioactivity
Electrospray deposition
Simulated body fluid
Issue Date: 31-Jan-2011
Citation: Thian, E.S., Li, X., Huang, J., Edirisinghe, M.J., Bonfield, W., Best, S.M. (2011-01-31). Electrospray deposition of nanohydroxyapatite coatings: A strategy to mimic bone apatite mineral. Thin Solid Films 519 (7) : 2328-2331. ScholarBank@NUS Repository.
Abstract: The biological performance of orthopaedic and oral metallic implants can be enhanced significantly by the application of bioactive coatings. In this work, a cost-efficient alternative to the traditional technique to produce a hydroxyapatite (HA) coating with a nanostructured feature onto a metallic implant surface at room temperature via electrospray deposition, is presented. To evaluate the bioactive capacity of these nanoHA (nHA) coatings in vitro, an acellular simulated body fluid soaking experiment and a human osteoblast (HOB) cell culture work were conducted. Under these physiological conditions, the accelerated apatite precipitation process occurred on the nHA-coated titanium surfaces as compared to the uncoated titanium surfaces. HOB cells developed mature cytoskeletons with distinct evidence of actin stress fibres and vinculin adhesion plaques, on these nHA coatings. Hence, this deposition technique holds great potential in producing high quality nHA coatings for biomedical applications. © 2010 Elsevier B.V. All rights reserved.
Source Title: Thin Solid Films
ISSN: 00406090
DOI: 10.1016/j.tsf.2010.11.035
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