Please use this identifier to cite or link to this item: https://doi.org/10.1243/09544119JEIM762
Title: Characterizing bubble dynamics created by high-intensity focused ultrasound for the delivery of antibacterial nanoparticles into a dental hard tissue
Authors: Ohl, S.-W.
Shrestha, A.
Khoo, B.C. 
Kishen, A.
Keywords: bubble dynamics
dentinal tubules
high intensity focused ultrasound
nanoparticles
pressure
Issue Date: 1-Nov-2010
Source: Ohl, S.-W., Shrestha, A., Khoo, B.C., Kishen, A. (2010-11-01). Characterizing bubble dynamics created by high-intensity focused ultrasound for the delivery of antibacterial nanoparticles into a dental hard tissue. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 224 (11) : 1285-1296. ScholarBank@NUS Repository. https://doi.org/10.1243/09544119JEIM762
Abstract: Hig hintensity focused ultrasound (HIFU) has been applied for drug delivery in various disease conditions. Delivery of antibacterial-nanoparticles into dental hard tissues may open up new avenues in the treatment of dental infections. However, the basic mechanism of bubble dynamics, its characterization, and working parameters for effective delivery of nanoparticles, warrants further understanding. This study was conducted to highlight the basic concept of HIFU and the associated bubble dynamics for the delivery of nanoparticles. Characterization experiments to deliver micro-scale particles into simulated tubular channels, activity of ultrasonic bubbles, and pressure measurement inside the HIFU system were conducted. Subsequently, experiments were carried out to test the ability of HIFU to deliver nanoparticles into human dentine using field emission scanning electron micrographs (FESEM) and elemental dispersive X-ray analysis (EDX). The characterization experiments showed that the bubbles collapsing at the opening of tubular channels were able to propel particles along their whole length. The pressure measured showed sufficient negative and positive pressure suggesting that the bubble grew to a certain size before collapsing, thus enabling the particles to be pushed. The FESEM and EDX analysis highlighted the ability of HIFU to deliver nanoparticles deep within the dentinal tubules. This study highlighted the characteristics and the mechanism involved of the bubbles generated by the HIFU and their capability to deliver nanoparticles. © 2010 Authors.
Source Title: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/59705
ISSN: 09544119
DOI: 10.1243/09544119JEIM762
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